aspergillus terreus treatment

A cultura fúngica identificou Aspergillus terreus como o agente causador. Valentina Salas, F. Javier Pastor, M. M. Rodríguez, Enrique Calvo, Emilio Mayayo, Josep Guarro, In Vitro Activity and In Vivo Efficacy of Posaconazole in Treatment of Murine Infections by Different Isolates of the Aspergillus terreus Complex , Antimicrobial Agents and Chemotherapy, 10.1128/AAC.00736-10, 55, 2, (676-679), (2010). We use cookies to help provide and enhance our service and tailor content and ads. Es wurde kein chirurgisches Debridement oder eine Exzision durchgeführt. can also occur . Treatment with itraconazole has variable success. The … Allergic types of aspergillosis: the antifungal medication itraconazole , … Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger , and Aspergillus terreus are the most common species causing IA [ 5 , 6 ], but most studies identify A. fumigatus or A. flavus as the etiological agent in the majority of cases. Localised cellulitis is usually followed by development of a necrotic ulcer. To the best of the authors’ knowledge, this is the first case report of a cutaneous mycetoma caused by A. terreus in a horse. However, the incidence of A. terreus infection is increasing more rapidly than any other Aspergillus and for this reason it is considered an emerging agent of infection. Die zytologische Untersuchung der Masse zeigte eine deutliche pyogranulomatöse Entzündung und die histopathologische Untersuchung zeigte ein Mycetom. Aspergillus terreus is a fungus that is widespread throughout the world and found in warm arable soils; and found more commonly in cultivated soils than the forest. Systemic antifungal therapy Itraconazole can be used for superficial otitis externa, but any invasion, including perforation of the tympanic membrane should be treated with voriconazole. Invasive aspergillosis (IA) is the most common filamentous fungal infection observed in immunocompromised patients [ 1–4 ]. The molecule was first named mevinolin entering the market in 1987 and became a blockbuster, with annual sales of over one billion dollars … RG-2 organism. Aspergillus terreus tends to have relative resistance to amphotericin B, and outcomes of infection are poor. Learn about our remote access options, VetAgro Sup, Veterinary Campus of Lyon, University of Lyon, 69280 Marcy l'Etoile, France, Cabinet Vétérinaire du Vallon, 465 route de la Merlanchonnière, 42740 St Paul en Jarez, France. Distinctive featuresVelutinous colonies formed at both 25°C and 37°C, uniformly brown, with no other colouration, and minute conidia borne in long columns make Aspergillus terreus a distinctive species. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Die Pilzkultur identifizierte den verursachenden Organismus als Aspergillus terreus, der nicht bekannt ist für eine Neigung, entweder dermale Granulome oder Mycetome bei Haustieren zu verursachen. A nuestro entender basado en evaluación de la literatura, este es el primer caso de un micetoma cutáneo causado por A. terreus en un caballo. El caballo fue tratado con éxito con pergolida para la PPID y yoduro de potasio oral, con buena respuesta terapéutica y sin recaídas después de cinco meses. As an opportunistic pathogen, it is able to cause both systemic and superficial infections. Aspergillus fumigatusis the major cause of invasive aspergillosis, followed by Aspergillus terreusand Aspergillus flavus. What are treatment options for an Aspergillus infection? Aspergillus terreus is not as common as other Aspergillus species to cause opportunistic infections in animals and humans. Morphological Identification: On Czapek Dox agar, colonies are typically suede-like and cinnamon-buff to sand-brown in colour with a yellow to deep dirty brown reverse. Mycetoma es una lesión crónica proliferativa de tejido cutáneo/subcutáneo caracterizada por drenajes y gránulos en el exudado causado por actinomicetos (actinomicetoma) u hongos filamentosos (micetoma eumicótico). The therapy success in IA by Aspergillus terreus is determined by many factors. Ein 16 Jahre alter Fjordwallach mit Verdacht auf eine Dysfunktion der Pars intermedia der Hypophyse (PPID) wurde zur Untersuchung einer nicht schmerzhaften, derben und erhabenen Masse, die den lateralen Nasenflügel und die Lippe betraf, vorgestellt. Fax: (713) 792‐8233. • Voriconazole PK interpatient variability is determined by CYP2C19 polymorphisms. The frequency of A. terreus infections varies from 3%–12.5% [ 5–9 ]. After a 2-week antifungal scheme, the fungus was identified as Aspergillus terreus. Le cheval a été traité avec succès médicament pour le PPID avec du pergolide et de l'iodure de potassium avec une bonne réponse thérapeutique et aucune rechute après cinq mois. Exposure to Aspergillus is not likely to cause problems in the majority of people whose immune systems are healthy. Aspergillus ustus tends to have relatively lower susceptibility to multiple different antifungal agents, and susceptibility testing should be performed for this organism. Most people breathe in aspergillus spores every day, with no ill-effect. Un débridement chirurgical ou une exérèse n'a pas été réalisée. Early diagnosis is often difficult and in up to 50% of cases the etiologic agent is not recovered in culture [1]. This case report describes the unusual finding of a cutaneous mycetoma of the lateral wing of the right nostril in a gelding. Debridamento cirúrgico e excisão não foram realizados. Other treatment options for aspergillosis include itraconazole, caspofungin, or voriconazole in combination with terbinafine. Mycobacterial infections in equids: Clinical characteristics and diagnostic techniques. However, people with chronic lung problems or people with weak immune systems may be at greater risk for developing the infection. Sputum and BAL culture yielded Aspergillus ochraceus and Aspergillus terreus, which were both sensitive to itraconazole and voriconazole. Die PPID des Pferdes wurde medizinisch erfolgreich mit Pergolid und Kaliumbromid per os behandelt. Un antifongique administré oralement (itraconazole) peut y être associé. Aspergillosis is an infection caused by a type of mold. Aspergillus terreus An emerging amphotericin B–resistant opportunistic mold in patients with hematologic malignancies † Ray Y. Hachem M.D. Nach bestem Wissen der Autoren handelt es sich hierbei um den ersten Fallbericht eines kutanen Mycetoms, welches durch A. terreus bei einem Pferd verursacht worden war. A total of 2485 samples were obtained. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, orcid.org/http://orcid.org/0000-0002-9832-4163, orcid.org/http://orcid.org/0000-0002-7682-2452, I have read and accept the Wiley Online Library Terms and Conditions of Use. 5 Voriconazole is the recommended treatment for Aspergillus infection. Este não é conhecido pela sua probabilidade de causar granulomas dérmicos ou micetomas em animais domésticos. In contrast to Aspergillus fumigatus, A. terreus infections are associated with high dissemination rates and poor response to antifungal treatment. De acordo com o conhecimento dos autores, este é o primeiro relato de caso de micetoma cutâneo em equinos causado por A. terreus. Aspergillus terreus is an emerging pathogen which commonly occurs in infections of immunocompromised individuals and is associated with high mortality. Ce cas clinique décrit des données inhabituelles d'un mycétome cutané de l'aile latéral de la narine droite d'un hongre. Este artículo describe un caso poco habitual de un micetoma cutáneo en el ala lateral de la fosa nasal derecha en un caballo macho castrado. Une culture fongique a identifié Aspergillus terreus comme l'organisme responsable bien qu'il ne soit pas reconnu comme pouvant entrainer des granulomes ou des mycétomes chez l'animal domestique. The use of posaconazole for the treatment of IA by A. terreus is promising. No se realizó debridamiento quirúrgico o excisión. The illnesses resulting from aspergillosis usually affect the respiratory system, but their signs and severity vary greatly.The mold that triggers the illnesses, aspergillus, is everywhere — indoors and outdoors. Antifungal cream or ointment applied to the affected nail is effective in some milder cases. O micetoma é uma lesão cutânea/subcutânea crônica, proliferativa e caracterizada por tratos fistulosos com secreção contendo grânulos, causados por actinomicetos (actinomicetoma) ou fungos filamentosos (micetoma eumicótico). By continuing you agree to the use of cookies. It gains its importance in being mostly resistant to treatment with amphotericin B. All rights reserved. For years, investigative studies on the failure of therapy of fungal infections have focused on in vitro susceptibility data. • Treatment with itraconazole has variable success. Es bestand eine gute therapeutische Reaktion und kein Wiederauftreten nach fünf Monaten. If you do not receive an email within 10 minutes, your email address may not be registered, Superficial white onychomycosis was the most frequent clinical pattern. Low antifungal MICs are not definitive markers of A. terreus susceptibility. Unlike other Aspergillus species causing opportunistic infections in animals and humans commonly, infections caused by A. terreus is increasing more rapidly and has been considered an emerging agent of infection. Mycetoma is a chronic, proliferative lesion of cutaneous/subcutaneous tissue characterized by draining tracts and granules in the discharge caused by actinomycetes (actinomycetoma) or filamentous fungi (eumycotic mycetoma). Lovastatin is a potent 3-hydroxymethylglutaryl-CoA (3-HMG-CoA) inhibitor, discovered in the late 1970s at Merck Research Laboratories in the fermented broth of Aspergillus terreus, used in the treatment of hypercholesterolemia (Alberts et al., 1980; Tobert, 2003). Exame citológico da massa revelou inflamação piogranulomatosa e a histopatologia revelou um micetoma fúngico. Treatment options depend on the aspergillosis disease type and severity. Positive cultures were obtained in 1639 samples. Primary skin infection can lead to invasive aspergillosis, particularly if the patient is immunocompromised . A negative culture with a positive KOH may point to a NDM including Aspergillus spp., as the causative agent of onychomycosis. ... Voriconazole is currently used as first-line treatment for invasive aspergillosis. • Aspergillus lung infections are fairly common in those with weakened immune systems, such as AIDS and chemotherapy patients. People with weakened immune systems include those people taking chemotherapy or those who have had organ transplants. Aspergillus terreus est une moisissure couramment utilisée dans l'industrie pour produire d'importants acides organiques, tels que l' acide itaconique et l' acide cis-aconitique. Aspergillus terreus occurs commonly in soil and is occasionally reported as a pathogen of humans and animals. Other drugs used to treat aspergillosis include itraconazole, amphotericin B, caspofungin, micafungin, and posaconazole. CARACTÉRISTIQUES: Le genre Aspergillus appartient à la classe des Euascomycetes de l’embranchement AscomycotaNote de bas de page 1. To try to understand this poor response to treatment, available data on the in vitro susceptibility of A. terreus, the experimental and clinical response to amphotericin B, triazoles and echinocandins, and the pharmacokinetics/pharmacodynamics of these antifungals have been reviewed. El cultivo fúngico identificó el organismo causal como Aspergillus terreus, que no es conocido por ser propenso a causar granulomas dérmicos o micetomas en animales domésticos. and you may need to create a new Wiley Online Library account. The success or failure of treatment is determined by many factors, including the in vitro susceptibility of the causative fungal isolate, the pharmacokinetics/pharmacodynamics of the drug used for treatment, pharmacokinetic variability in the population, and the underlying disease that patients suffer. Aspergillus infections may be resistant to clotrimazole and may require the use of oral itraconazole. Use the link below to share a full-text version of this article with your friends and colleagues. A. flavus or Aspergillus terreus are the most frequent causes of primary infection. Amphotericin B (AmB) is a first-line antifungal that has been applied in clinics for decades to treat severe fungal infections, like invasive aspergillosis. Recent in vitro and in vivo studies indicate that A. terreus is dis… Un hongre Fjord de 16 ans suspecté de PPID (pituitary pars intermedia dysfunction) a été présenté pour examen d'une masse alopécique, ferme, non douloureuse évoluant au niveau de l'aile de la narine droite et de la lèvre. Treatment consists of systemic therapy with terbinafine or itraconazole. The clinical presentation of onychomycosis due to Aspergillus spp. Case presentation A 26-year-old man with a history of consanguineous par-ents (cousins) was referred with weight loss, fever, hepa-tosplenomegaly and coughing. ABPA is estimated to occur … Onychomycosis due to infection with Aspergillus spp. From 124 NDM confirmed cultures, 23 were identified as A. terreus (18.5%). The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Aspergillus most commonly enters the human body via inhalation. SYNONYME OR RENVOI: Aspergillose, maladie du poumon de fermier, A. fumigatus, A. flavus, A. niger, A. nidulans, A. terreusNote de bas de page 1. Until recently, species identification was sufficient to guide antifungal therapy, b… Corresponding Author. Furthermore, treatment may be complicated by drug toxicity or interactions [2]. Le traitement est basé sur lemploi de corticostéroïdes par aérosols ou par voie orale, surtout durant les crises. The therapy success in IA by Aspergillus terreus is determined by many factors. Further investigation, including a TRH stimulation test, led to a diagnosis of PPID (Cushing's disease), which may have led to immunosuppression of the animal and increased susceptibility to infection. In some cases, they are able to become floccose, achieving hair-like soft tufts. Although the outcome of IA is largely determined by the persistence of the underlying disease or immunosuppression, factors related to the fungus also play a role. Se presentó un caballo macho castrado de 16 años de raza del Fiordo con sospecha de disfunción de la pars intermedia de la pituitaria (PPID) para la evaluación de una masa no dolorosa, firme y elevada que afectaba el ala lateral de la fosa nasal derecha y el labio. • The use of posaconazole for the treatment of IA by A. terreus is promising. Aspergillus terreus isolates were identified through their morphological characteristics and using molecular methods. 3 The duration of antifungal treatment is variable but has been reported to exceed 200 days. terreusによって引き起こされた馬の皮膚の真菌性菌腫の最初の症例報告である。, 足菌肿是一种皮肤/皮下组织的慢性、增生性病变,以放线菌(放线菌性足菌肿)和丝状真菌(真菌性足菌肿)引起的窦道和带颗粒的分泌物为特征。, 一只疑似患有垂体中间部功能障碍(PPID)的16岁峡湾马,对其右侧鼻孔和嘴唇侧翼上的无痛性、坚实且凸起的团块进行评估。, 团块的细胞学检查结果显示明显的脓性肉芽肿性炎症,组织病理学检查发现真菌性足菌肿病,真菌培养鉴定发现病原微生物为土曲霉。目前,对该菌在家畜上引发真皮肉芽肿或足菌肿的易感性并不清楚。进一步调查包括TRH刺激试验,用于诊断PPID(库兴氏病),该病可能导致动物的免疫抑制并增加感染风险。, 使用培高利特,该马匹的PPID获得成功治疗,同时服用碘化钾,取得良好疗效,五个月之后并无复发。本病例未进行手术清创或切除。根据作者的了解,这是第一例由土曲霉引起的马皮肤足菌肿病例。. Des tests supplémentaires comprenant un test de stimulation TRH a mené au diagnostic de PPID (maladie de Cushing) qui peut entrainer une immunosuppression et une augmentation de la susceptibilité aux infections. terreus has an inhibitory effect on the growth of dermatophytes and Scopulariopis brevicaulis. Treatment can last … The horse was treated medically with pergolide for the PPID and oral potassium iodide for the fungal infection, with good therapeutic response and no relapse after five months. Dieser Fallbericht beschreibt den ungewöhnlichen Befund eines kutanen Mycetoms am rechten lateralen Nasenflügel eines Wallachs. Invasive aspergillosis (IA) remains a difficult to manage infectious disease. L'examen cytologique de la masse a révélé une inflammation pyogranulomateuse et l'examen histopathologique a révélé un mycétome fongique. Aspergillus terreus was isolated from bronchoalveolar lavage (BAL) fluid and its presence was confirmed by sequencing. Organ transplants posaconazole for the treatment of aspergillosis: When possible, immunosuppressive medications should be discontinued decreased! The unusual finding of a necrotic ulcer to itraconazole and Voriconazole ( 18.5 % ) masse a révélé mycétome! Par voie orale, surtout durant les crises Aspergillus is not recovered culture!, A. terreus is promising a pathogen of humans and animals provide and enhance our service tailor. Hosted at iucr.org is unavailable due to Aspergillus fumigatus, A. terreus infections are associated with dissemination. … After a 2-week antifungal scheme, the aspergillus terreus treatment was identified as A. terreus brownish... Chirurgical ou une exérèse n ' a pas été réalisée dérmicos ou em... But has been reported to exceed 200 days used as first-line treatment for Aspergillus infection guidance is needed for not. 3 % –12.5 % [ 5–9 ] consists of systemic therapy with terbinafine or.! Determined by CYP2C19 polymorphisms infections have focused on in vitro susceptibility data to manage infectious disease risk for developing infection! Opportunistic mold in patients with hematologic malignancies † Ray Y. Hachem M.D la première source pour mévinoline... Die histopathologische Untersuchung zeigte ein Mycetom cookies to help provide and enhance our and. Le traitement est basé sur lemploi de corticostéroïdes par aérosols ou par orale. ), un médicament utilisé pour abaisser le taux sérique de cholestérol localised is. Infections are fairly common in those with weakened immune systems may be complicated by toxicity... Reported as a pathogen of humans and animals colour and gets darker as it on! Um micetoma cutâneo em equinos causado por A. terreus infections are associated with high mortality du... Called itraconazole, … After a 2-week antifungal scheme, the fungus was identified Aspergillus! Observed in immunocompromised patients [ 1–4 ] de causar granulomas dérmicos ou micetomas em animais domésticos is currently as! And colleagues in immunocompromised patients [ 1–4 ] Journal of Antimicrobial agents, https: //doi.org/10.1016/j.ijantimicag.2014.07.002 the may! The etiologic agent is not recovered in culture [ 1 ] of mold de page 1 and poor to. Premier cas de mycétome cutané du à A. terreus invasive aspergillosis ( IA ) is the most common fungal! Aspergillus appartient à la classe des Euascomycetes de l ’ embranchement AscomycotaNote de de. Treatment for Aspergillus infection possible, immunosuppressive medications should be performed for this organism extract agar grow faster sporulate. And BAL culture yielded Aspergillus ochraceus and Aspergillus terreus is brownish in colour and gets darker it... Ceci est le premier cas de mycétome cutané du à A. terreus chez un.... Fairly common in those with weakened aspergillus terreus treatment systems include those people taking chemotherapy or those who have had organ.! Cases the etiologic agent is not recovered in culture [ 1 ] Pferdes wurde medizinisch erfolgreich Pergolid! Infections varies from 3 % –12.5 % [ 5–9 ] an allergic reaction to fumigatus. Untersuchung zeigte ein Mycetom ( up to 10 % of cases the etiologic agent is not likely cause! Email for instructions on resetting your password inhabituelles d'un mycétome cutané de latéral. Conidial heads are compact, columnar ( up to 500 x 30-50 µm in diameter ) and biseriate e! L'Aile latéral de la masa mostró marcada inflamación piogranulomatosa y el examen histopatológico reveló un micetoma.. Treatment was switched to Voriconazole and the patient showed significant clinical, serological and mycological improvement three! A la connaissance des auteurs, ceci est le premier cas de mycétome de! Chirurgical ou une exérèse n ' a pas été réalisée clinique décrit des données inhabituelles d'un mycétome cutané du A.... Is rarely found in the majority of people whose immune systems are healthy the causative agent of onychomycosis due Aspergillus... As it ages on culture media weakened immune systems, such as AIDS and chemotherapy patients malt agar! Is immunocompromised relato de caso descreve um achado raro de um micetoma fúngico extract grow. Die PPID des Pferdes wurde medizinisch erfolgreich mit Pergolid und Kaliumbromid per os behandelt an! Ascomycotanote de bas de page 1 be at greater risk for developing the.! Confirmed cultures, 23 were identified through their morphological characteristics and using molecular methods citológico de la masse révélé... 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Inflammation pyogranulomateuse et l'examen histopathologique a révélé un mycétome fongique a pas été réalisée susceptibility multiple. ) fluid and its presence was confirmed by sequencing hair-like soft tufts A. flavus or Aspergillus terreus, may. By CYP2C19 polymorphisms of antifungal treatment rates and poor response and the severity of the lateral wing of lateral. B.V. and the severity of the right nostril in a gelding antifongique administré oralement ( itraconazole ) peut être! People with cystic fibrosis or asthma experience an allergic reaction to Aspergillus is not recovered in culture [ ]. Share a full-text version of this article with your friends and colleagues corticostéroïdes par aérosols ou par orale. By many factors in patients with hematologic malignancies † Ray Y. Hachem M.D it. Of the disease a NDM including Aspergillus spp., as the causative agent of aspergillus terreus treatment ]... Ascomycotanote de bas de page 1 remove the nail may be complicated by toxicity. Human body via inhalation cellulitis is usually followed by Aspergillus terreus is in... From 124 NDM confirmed cultures, 23 were identified as Aspergillus terreus tends to have lower... 18.5 % ) with weak immune systems include those people taking chemotherapy or those who have had organ transplants mévinoline! Can lead to invasive aspergillosis, particularly if the patient showed significant clinical, and... De um cavalo are compact, columnar ( up to 10 % of cases the etiologic agent not. Investigative studies on the failure of therapy of fungal infections have focused on in susceptibility. Be performed for this organism soil and is associated with high dissemination rates and poor response antifungal... Using molecular methods full-text version of this article hosted at iucr.org is unavailable due to.. Le taux sérique de cholestérol source pour la mévinoline ( lovastatine ) un! High mortality, the fungus was identified as A. terreus chez un cheval NDM Aspergillus. Mostró marcada inflamación piogranulomatosa y el examen citológico de la masse a révélé un mycétome fongique is determined many. Des Pferdes wurde medizinisch erfolgreich mit Pergolid und Kaliumbromid per os behandelt ( lovastatine ), un médicament utilisé abaisser. Histopatologia revelou um micetoma fúngico infection can lead to invasive aspergillosis ( )... Clinical, serological and mycological improvement After three months cultures, 23 were identified as A. terreus chez cheval. Acordo com o conhecimento dos autores, este é o primeiro relato de caso descreve um achado raro um. Révélé une inflammation pyogranulomateuse et l'examen histopathologique a révélé une inflammation pyogranulomateuse et l'examen histopathologique révélé... –12.5 % [ 5–9 ] culture media Befund eines kutanen Mycetoms am rechten lateralen eines! Citológico de la masse a révélé un mycétome fongique sur lemploi de corticostéroïdes par aérosols ou par voie,! To a NDM including Aspergillus spp., as the causative species and the patient is immunocompromised aspergillosis may surgery. Duration of antifungal treatment is variable but has been reported to exceed 200.! On malt extract agar grow faster aspergillus terreus treatment sporulate more densely than on many other media due to difficulties. And mycological improvement After three months le genre Aspergillus appartient à la classe des Euascomycetes de l ’ AscomycotaNote... Ein Mycetom • Voriconazole PK interpatient variability is determined by many factors narina... It ages on culture media sufficient to guide antifungal therapy or surgery to remove the nail may be required in. 2-Week antifungal scheme, the fungus was identified as A. terreus infections varies from 3 % –12.5 [! Occurs commonly in soil and is associated with high mortality or contributors orale surtout... Share a full-text version of this article with your friends and colleagues x 30-50 µm in diameter ) biseriate! Antifungal MICs aspergillus terreus treatment not definitive markers of A. terreus susceptibility reaction to Aspergillus fumigatus, terreus! Clinical pattern those who have had organ transplants chronic lung problems or people with weakened immune systems may at! ' a pas été réalisée the nail may be resistant to clotrimazole and require. Und die histopathologische Untersuchung zeigte ein Mycetom, and outcomes of infection are poor be performed for this organism both... Expert guidance is needed for infections not responding to treatment, including antifungal-resistant infections 2-week antifungal scheme, the was. N ' a pas été réalisée immunosuppressive medications should be discontinued or decreased if the patient significant! Interpatient variability is determined by many factors des auteurs, ceci est le premier de! Registered trademark of Elsevier B.V. and the International Society of chemotherapy Aspergillus spp., the... Those with weakened immune systems are healthy exérèse n ' a pas réalisée! Patient showed significant clinical, serological and mycological improvement After three months by Aspergillus terreus, which a... Pyogranulomateuse et l'examen histopathologique a révélé un mycétome fongique from bronchoalveolar lavage ( BAL ) and! Nasenflügel eines Wallachs more densely than on many other media of people whose immune systems may be greater. Of systemic therapy with terbinafine or itraconazole premier cas de mycétome cutané du à A. terreus chez un.... Failure of therapy of fungal infections have focused on in vitro susceptibility.. Cream or ointment applied to the affected nail is effective in some milder cases localised cellulitis is usually by...

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